Mitochondria: Masters of Epigenetics

Svetlana Dzitoyeva Progress in mitochondrial epigenetics

Mitochondria, intracellular organelles with their own genome, have been shown capable of interacting with epigenetic mechanisms in at least four different ways. First, epigenetic mechanisms that regulate the expression of nuclear genome influence mitochondria by modulating the expression of nuclear-encoded mitochondrial genes. Second, a cell-specific mitochondrial DNA content (copy number) and ...

Progress in mitochondrial epigenetics.

Mitochondria, intracellular organelles with their own genome, have been shown capable of interacting with epigenetic mechanisms in at least four different ways. First, epigenetic mechanisms that regulate the expression of nuclear genome influence mitochondria by modulating the expression of nuclear-encoded mitochondrial genes. Second, a cell-specific mitochondrial DNA content (copy number) and ...

Role of Epigenetics in Biology and Human Diseases

For a long time, scientists have tried to describe disorders just by genetic or environmental factors. However, the role of epigenetics in human diseases has been considered from a half of century ago. In the last decade, this subject has attracted many interests, especially in complicated disorders such as behavior plasticity, memory, cancer, autoimmune disease, and addiction as well as neurod...

CALL FOR PAPERS Epigenetics and Epigenomics The mitochondrial side of epigenetics

Castegna A, Iacobazzi V, Infantino V. The mitochondrial side of epigenetics. Physiol Genomics 47: 299 –307, 2015. First published June 2, 2015; doi:10.1152/physiolgenomics.00096.2014.—The bidirectional cross talk between nuclear and mitochondrial DNA is essential for cellular homeostasis and proper functioning. Mitochondria depend on nuclear contribution for much of their functionality, but the...

The Prospects of Epigenetics in Neuroscience